Classical conditioning (CC) refers to the general paradigm for scientific studies of learning and memory initiated by Pavlov and his followers. As a model system associative learning in human and animals, CC continues to play a central role in research and an expanding role in evaluating disorders of learning and memory (aging, drug abuse, teratology). The book is aimed at the growing population of scientists and medical specialists who employ CC methods. Despite the current high level of interest in CC within neuroscience. There is presently no single source that provides up-to-date comprehensive coverage of core topics. CC is a very large field. Nevertheless, some organisms and behaviors have dominated the neuroscience scene. Foremost of these are classical eyeblink conditioning (rats, cats, rabbits, and humans) and fear conditioning. This handbook of CC focuses on these systems.