The book explores cost-effective and efficient supply chain management to achieve resilience in the post-COVID environment. Qualitative, quantitative, case studies, and systematic literature reviews are made in the book. The book follows a didactic approach through which it informs global researchers and practitioners to deal with the most significant insights on future supply chains with a more in-depth analysis of post-COVID opportunities and challenges. In particular, this book provides an in-depth assessment of disruptive supply chain management in certain industrial contexts and explores various Industry 4.0 and Industry 5.0 technologies to achieve resilience. The book is used as a supplemental textbook for study within university level programs, at late undergraduate and graduate levels, in faculties of business and management, engineering systems, information systems, education, and computing.