This four-volume set, IFIP AICT 792-795, constitutes the proceedings of the 22nd IFIP WG 12.5 International Conference on Artificial Intelligence Applications and Innovations, AIAI 2026, which was held in Chania, Crete, Greece, during July 16-19, 2026. The 122 full papers and 5 short papers included in these volumes were carefully reviewed and selected from 288 submissions. The papers cover the following topical sections: Part I: Core ML Methods, Optimization & Learning Theory; NLP, Speech, Text Mining & Document Analytics; and Medical Imaging, Diagnostics & Biomedical Decision Support; Part II: LLMs, RAG, Agentic AI & Automated Reasoning; Computer Vision, Imaging & Multimodal Perception; and Robotics, Autonomous Systems, Transport & Planning; Part III: Health Informatics, Rehabilitation & Public Health AI; Cybersecurity, Privacy, Distributed Systems & Trustworthy AI; and Industrial, Manufacturing, Construction & Engineering AI; Part IV: Environmental, Agriculture, Energy & Sustainability AI; Finance, Business, Markets & Innovation Analytics; Education, Human Factors, HCI & Social/Behavioral Analytics; and Graph, Recommender & Semantic Information Systems.