Faced with climate changes, pest pressure on plants is increasing and new pest complexes are appearing, for which plant protection solutions are not yet available. The reduction of anthropic pressure on agroecosystems requires a reduction in the use of chemical inputs and the promotion of biocontrol approaches. In this book, we present new advances on plant disease management that are emerging from research outputs. The ability of biocontrol products to directly (e.g. production of antimicrobial peptides or quorum quenching activities by microorganisms, use of plant or agro-industrial by-products as biopesticides, etc.) or indirectly (e.g. via the increase of plant defense or plant growth pathways) protect plants against pathogens and pests is also considered. We also address new strategies like the development of phage-based biocontrol products and those that consider the plant as a holobiont and plant microbiota as targets of biocontrol treatments. The important question of the current regulatory process needed to launch plant production products on the market is also addressed, such as methods to evaluate their environmental impact.