Since 1971, UNESCOs Man and the Biosphere (MAB) Programme has embraced a number of principles that link the political, scientific and academic spheres. Biosphere Reserves and Sustainable Development Goals 1 presents these areas as privileged spaces for experimenting with operating methods specific to cross-cutting objectives and issues. These areas encourage the development of interdisciplinary research, supported by a worldwide network to disseminate experience, approaches and knowhow. The various global and local political scales are linked here, with different consequences for the reconfiguration of local political arenas, for specific modes of development linked to a renewed relationship with knowledge, powers and institutions, and for renewed relationships between the worlds of science, education and territorial governance.