This new textbook uses a problem-based learning (PBL) approach for teaching the fundamentals of kinesiology and biomechanics to undergraduate and graduate students in the biomedical, rehabilitative, and exercise science fields. Case vignettes and problems for each major region of the body are presented – cervical spine, thoracic spine and rib cage, lumbar spine and pelvis, shoulder girdle, elbow/forearm, wrist, hand, hip, knee, and ankle/foot. For the cases on the spine and upper extremity, biomechanics of posture are included; for cases involving the hip, knee, and ankle/foot, an extensive study of gait analysis is also incorporated. These case vignettes are not preceded by chapters that provide foundational information. Rather, relevant anatomical, biomechanical, and other information needed to solve/explain each case are embedded in the relevant chapters presenting the clinical cases.