This book discusses the risks, challenges, and opportunities of cross-border work and life from a multidisciplinary and multilevel perspective, including (a) the individual, (b) the social and organizational, and (c) the regional levels, taking into consideration the diverse and multilayered social, economic, technological, and jurisdictional issues involved. Emerging public policies and advanced information technologies (IT) have created new opportunities for work and life that thrive in global value chains and markets. Life, in general, and work, in particular, are increasingly organized across borders of various kinds and are subject to rapid change. At the same time, life and work have been determined by 19th and 20th century infrastructures and technologies. As a consequence, new strategies and measures are required for both physical and virtual work and life spaces.