This first volume of a two-volume work focuses on the multifaceted world of donkeys, mules and hinnies, exploring their origins, breeds, conservation and management practices by examining historical, genetic, and sociocultural perspectives. The complete two-volume textbook is an indispensable A to Z guide aimed at veterinarians, students and donkey owners alike, providing a richly illustrated in-depth practical approach to understanding the anatomy, physiology, diseases and treatment of the various equine species. This volume serves as authoritative guide to the evolution and global dispersal of donkeys, the quantitative and molecular genetics behind, as well as the roles these animals play in production and trade. Readers discover the intricacies of dairy donkey farming and get detailed insights into donkey milk and gelatine industries. The book highlights the practical aspects of donkey and mule husbandry, such as saddle fitting, harnessing, nutrition, and veterinary care. Moreover, the authors provide a comprehensive analysis of the anatomical differences between donkeys and mules, their implications for veterinary procedures, and the challenges of clinical parasitology and podiatry, offering practical guidance for maintaining their health and well-being. Written in an easy-to-understand style, this textbook is the first of its kind to provide detailed medical information on donkeys, mules and hinnies.