This book provides an integrated understanding of drug-resistant infections and antimicrobial resistance, bringing together microbiology, clinical medicine, public health, policy, surveillance, antimicrobial stewardship, and the One Health approach. Divided into five sections, the book discusses the evolution of antibiotics and examines rational antibiotic use while addressing key drivers of AMR and evidence-based containment strategies. It explores global initiatives, One Health approaches, and the roles of health systems, veterinary practice, environmental sectors, private healthcare providers, and civil society in mitigating AMR. Further chapters discuss the AMR surveillance across human and animal health sectors, antimicrobial consumption monitoring, stewardship programs, infection prevention, and vaccination strategies. The book also discusses research priorities, challenges in antibiotic development, alternative therapeutic approaches, and communication frameworks supporting behavior change and sustainable AMR control. The book is relevant for policy makers, medical professionals, veterinary professionals, civil society stakeholders, environmentalists, and communication scientists working in antimicrobial resistance prevention, public health planning, and global health policy.