This book explores international biomedical research and development on the early diagnosis of Alzheimers disease. It offers timely, multidisciplinary reflections on the social and ethical issues raised by promises of early diagnostics and asks under which conditions emerging diagnostic technologies can be considered a responsible innovation.  The initial chapters in this edited volume provide an overview and a critical discussion of recent developments in biomedical research on Alzheimers disease. Subsequent contributions explore the values at stake in current practices of dealing with Alzheimers disease and dementia, both within and outside the biomedical domain. Novel diagnostic technologies for Alzheimers disease emerge in a complex and shifting field, full of controversies. Innovating with care requires a precise mapping of how concepts, values and responsibilities are filled in through the confrontation of practices. In doing so, the volumeoffers a practice-based approach of responsible innovation that is also applicable to other fields of innovation.