This monograph offers an in-depth understanding of the scientific basis of anterior cruciate ligament treatment (ACL) and clinical application based on the authors more than forty-year experience. Starting with basic science such as anatomy and biomechanics, the following chapters explain the practical diagnostic methods using manual examination and imaging. It then provides reconstructive surgery techniques on specific cases, postoperative rehabilitation for early and safe return to sports, and detailed evaluation methods with a view to prognosis. It also offers a rationale for evidence-based treatment strategies and evaluation of the treatment for further improvement. The supplemental information offers readers a revitalizing alternative to current methods. Essence of Anterior Cruciate Ligament – Scientific Evidence and Clinical Practice of ACL is a must-read for physicians, orthopaedic surgeons, physiotherapists, and athletic trainers to treat and rehabilitatepatients. The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.