The so-called "Non-conventional geophysical-geochemical exploration methods" are used, in the particular case of oil and gas exploration, for the detection and mapping of active microseepage of light hydrocarbons with a vertical nature on the gas-oil accumulations. The non-seismic exploration methods used in Cuba are: Remote Sensing, Gravimetry, Aeromagnetometry, Airborne Gamma Spectrometry (AGS) and Morphometry (non-conventional, from the Digital Elevation Model 90x90m). The AGS also classifies, as a non-conventional geophysical-geochemical method, together with the Redox Complex. Besides, it is of interest to know the geological-structural framework where these microseepage occur. That is why the benefits of using these methods (excluding Redox Complex), prior to their integration with geological and seismic data, translate into a first approximation, valid for an initial understanding of geology and mapping of favourable areas of possible gas-oil interest. Finally, from the implementation of these methods (including Redox Complex), perspective sectors for oil and gas are obtained, once the integration with geology and seismic has been carried out. The book presents a brief theoretical account of the methods used and, as practical results, a set of perspective sectors of possible interest for exploration in Cuba. As a complementary result, the book also offer an evaluation of the areas that meet the petroleum-geologist premises for the presence of large accumulations of high quality oil in Cuba.