An indispensable reference for any practicing synthetic organic or medicinal chemist, this book continues the tradition of Greene as comprehensive in the overall scope of coverage, providing the most relevant and useful examples to illustrate each methodology. • Presents valuable material, on the application of protective groups in organic chemistry, that is not easily found by casual searching • Helps chemists to plan, investigate, and carry out organic syntheses in an efficient manner • Adds over 2800 new references to update since the publication of the last edition • Reviews of the prior edition: An essential bible for the library or personal bookshelf of chemists performing complex synthesis. (CHOICE, May 2007) ...the most up-to-date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy... (Journal of Medicinal Chemistry, March 8, 2007) ...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups. (Journal of the American Chemical Society, January 31, 2007)