This work demonstrates that hand and wrist rehabilitation calls for precise anatomical, biomechanical, and physiological expertise, as well as mastery of manual techniques and targeted physiotherapy. Particular attention is given to the complementarity between theoretical knowledge and practical aspects; accordingly, refreshers on the underlying theory; descriptions of the rehabilitation protocols and the specific manual and instrumental techniques; and the type of orthesis used depending on the delay of healing are provided for each pathology. This publication will appeal to a broad readership, from physiotherapists and occupational therapists, to surgeons and practitioners specialized in physical rehabilitation, to students in the fields of physiotherapy and occupational therapy.