This book brings together experts in the field of maxillofacial and head and neck oncology to provide a comprehensive clinical and translational update on oral cancer that focuses especially on prognosis. Readers will find up-to-date information on disease staging and the pathological, genetic, and surgical factors that affect patient outcomes. Individual chapters describe the most recent advances in radiotherapy, chemotherapy, and immunotherapy, again with careful analysis of the treatment-related factors relevant to response and survival. Management of premalignant lesions and risk factors for malignant transformation are discussed, and the latest knowledge on chemoprevention is presented. Further topics to be addressed include reconstruction of oral cancer defects, salvage options in the event of recurrence, and the prediction of quality of life following treatment. The book will be of value to all clinicians who care for patients with oral cancer in their everyday practice.