This edited book focuses on the multidimensional aspects of the technological megatrends shaping our global economic systems social, economic, and geopolitical order in the face of uncertainties. With continued shocks, economic downturns, socio-political crises, climate change, and waves of pandemics that pose an existential threat, technological forces have significant effects in defining our path. In this book, by focusing on recent innovations and technological megatrends, the authors assess the sustainability of such human developments in the face of uncertainty. The book analyses the core developments, and trending tech solutions that pause challenges and bring opportunities for businesses and the economies as our global economy emerges from the devastating economic downturn caused by the COVID-19 pandemic and beyond. The book appeals to professionals wanting to assess how technological developments and innovation will impact their areas, but also to researchers interested in the impact on businesses, industries and economies.