This book constitutes the refereed proceedings of the First International Conference on Intelligent, Secure, and Dependable Systems in Distributed and Cloud Environments, ISDDC 2017, held in Vancouver, BC, Canada, in October 2017. The 12 full papers presented together with 1 short paper were carefully reviewed and selected from 43 submissions. This book also contains 3 keynote talks and 2 tutorials. The contributions included in this proceedings cover many aspects of theory and application of effective and efficient paradigms, approaches, and tools for building, maintaining, and managing secure and dependable systems and infrastructures, such as botnet detection, secure cloud computing and cryptosystems, IoT security, sensor and social network security, behavioral systems and data science, and mobile computing.