This textbook provides an educational foundation for undergraduate students interested in the field of health informatics and serves as a resource for further study, including future classes and certification exams. The majority of textbooks currently available in this field are targeted toward graduate level students and/or specific subfields of health informatics. This textbook fills a critical gap by offering a comprehensive, accessible resource tailored to baccalaureate students. It also provides instructors with guidance and resources for administering undergraduate level classes that meet foundational domains (and their corresponding knowledge, skills and attitudes) used in the assessment of programs for health informatics undergraduate program accreditation.   Introductory Textbook in Health Informatics has been written by subject matter experts and edited by members of the AMIA Baccalaureate Educational Committee, who have national representation and experience in curriculum development at this level. Additionally, faculty with experience in accreditation and site visits have contributed to the textbook making this a critical addition to the literature for use by undergraduate trainees and program directors within health informatics. It also represents a key foundational text for those taking their Clinical Informatics sub-specialty boards.