This book demonstrates how hospitals can be transformed into dynamic, patient-centered, and cost-effective organizations. It describes systems for providing safe, high-quality medical services and outlines the importance of data for health outcomes. In this regard, the book underscores the importance of decision-making and delegation, as well as the effective use of administrative staff, new technologies, and evidence-based medicine to benefit patients and boost efficiency. At the same time, it emphasizes the importance of applying metrics to improve cost-effectiveness. Although primarily intended as a hands-on book for clinical leaders, it also considers hospitals from a broader societal perspective, making it of interest to leaders at all organizational levels in hospitals and to policymakers alike.