MicroRNAs as Tools in Biopharmaceut - E-book

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Micrornas As Tools In Biopharmaceutical Production - ENG

Niall Barron

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Sinopsis

ISBN:	9789400751286
Formato:	ePub
Idioma:	Inglés
Editorial:	Springer Nature
Tema:	Medicina
Subtema:	Farmácia
Año de publicación:	2012-11-15

Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells, Â miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient/stable disregulation, Knockout.

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