The book focuses on the rampant use of higher-dose antibiotics in human routine consumption and how it leads to bacterial resistance to multiple drugs. Book chapters focus on the result of their overuses and concomitant misuses, and how antibiotics have become synonymous with the unending hellish experience that is antimicrobial resistance by pathogenic microbes. It also talks about the challenges associated with the treatment of bacterial infections and challenges to mankind due to the development of high rates of antibiotic resistance. This book also provides information about developments of antibacterial drugs from natural sources. In addition, it also covers different computational approaches used for antibacterial drug development from natural sources in recent times. Finally, the book also elucidates a detailed outline of bacterial resistance status, current treatment methods, natural products as an opportunity for the development of potent druggable candidates, and methods of antibacterial drug development. This book serves as a great resource for students, researchers, and academicians in the field of pharmacology.