The two-volume set CCIS 1332 and 1333 constitutes thoroughly refereed contributions presented at the 27th International Conference on Neural Information Processing, ICONIP 2020, held in Bangkok, Thailand, in November 2020.* For ICONIP 2020 a total of 378 papers was carefully reviewed and selected for publication out of 618 submissions. The 191 papers included in this volume set were organized in topical sections as follows: data mining; healthcare analytics-improving healthcare outcomes using big data analytics; human activity recognition; image processing and computer vision; natural language processing; recommender systems; the 13th international workshop on artificial intelligence and cybersecurity; computational intelligence; machine learning; neural network models; robotics and control; and time series analysis. * The conference was held virtually due to the COVID-19 pandemic.