This book discusses the complex ways in which the novel offers a vibrant arena for critically engaging with our contemporary world and scrutinises the genres political, ethical, and aesthetic value. Far-reaching cultural, political, and technological changes during the past two decades have created new contexts for the novel, which have yet to be accounted for in literary studies. Addressing the need for fresh transdisciplinary approaches that explore these developments, the book focuses on the multifaceted responses of the novel to key global challenges, including migration and cosmopolitanism, posthumanism and ecosickness, human and animal rights, affect and biopolitics, human cognition and anxieties of inattention, and the transculturality of terror. By doing so, it testifies to the ongoing cultural relevance of the genre. Lastly, it examines a range of 21st-century Anglophone novels to encourage new critical discourses in literary studies.