This book reviews the potential effect of diet modification, lipids, and carbohydrate consumptions, vitamin supplementation, antioxidants, and nutraceuticals in the prevention and management of Alzheimers disease. The initial chapter of the book presents the pathophysiological mechanisms, risk factors, genetic predisposition, disease diagnosis, pathology, and current treatment strategies against Alzheimers disease. It also highlights recent developments in exploring novel compounds for the prevention and treatment of Alzheimers disease. Subsequently, it highlights the therapeutic effect and regulation of molecular targets by natural compounds. The book discusses the potential of natural compounds in inhibiting the formation and deposition of Aβ peptides. It examines the natural compounds in modulating intracellular signaling molecules and enzymes involved in the pathogenesis of Alzheimers disease. In summary, this book helps understand the role of natural compounds as a therapeutic approach in amelioration and preventing detrimental effects of Alzheimers disease.