This volume constitutes the refereed proceedings of the Confederated International  International Workshop on Enterprise Integration, Interoperability and Networking (EI2N ), Fact Based Modeling ( FBM),  Industry Case Studies Program ( ICSP ), and International Workshop on Methods, Evaluation, Tools and Applications for the Creation and  Consumption of Structured Data for the e-Society (Meta4eS), held as part of OTM 2018 in October 2018 in Valletta, Malta. As the three main conferences and the associated workshops all share the distributed aspects of modern computing systems, they experience the application pull created by the Internet and by the so-called Semantic Web, in particular developments of Big Data, increased importance of security issues, and the globalization of mobile-based technologies.