This book presents a vision for a new and holistic organisational system and paradigm—panonomics. Panonomics proposes a comprehensive understanding of ‘place’ and an expansive understanding of ‘time’ as the foundational framework for a new system. Presented as a fitting response to a pandemic and in support of progress through the 4.0 age, panonomics asserts an onward and upward directionality towards a shared mission of human survival and planetary sustainability, characterised as the continuous accumulation of time. While ambitious in both scope and proposals, the book sets out a theoretical context and framework, modelling how the principles of panonomics can be applied to current and emerging policy and asserting that, through expanding and extending our understandings of key concepts such as place, time and innovation, we can break free from the confines of current and regressive economic structures, systems and institutions to reset, reframe and advance collectively towards a ‘future now’.