PEGylated Protein Drugs: Basic Scie - E-book

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Pegylated Protein Drugs: Basic Science And Clinical Applications - ENG

Francesco M. Veronese

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Sinopsis

ISBN:	9783764386795
Formato:	Page Fidelity
Idioma:	Inglés
Editorial:	Springer Nature
Tema:	Medicina
Subtema:	Farmacología
Año de publicación:	2009-12-30

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

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