This practical manual delivers clinically relevant and updated concepts as per the Competency-Based Medical Education (CBME) curriculum.• This student-friendly practical manual has an observation table column at the end of most of the chapters.• Competencies with specific learning objectives (SLOs) are mentioned at the start of each chapter.• The CBME curriculum mandates the skill certification of competencies in the log book. By using this practical manual, students can directly fill their responses, in the predrawn tables. Thus, the practical hours can be completely used for developing psychomotor skills and skill certification.• Full-colour photos, labelled diagrams, and illustrations will help to precisely understand and perform the procedural steps in clinical examination.• Clinical scenarios/charts/graphs/calculations were given in the last few chapters.• Discussion questions with answers will be useful for the students to score more during the practical viva voice• Examples of practical OSCE were provided at the end of most of the chapters.• Amphibian and Mammalian experiments with graphs were provided for postgraduate students.• This book will be useful to MBBS, MD and MSC physiology students, dental, paramedical, and allied health science students.