This book offers a multidisciplinary and in-depth analysis of the One Health approach. The holistic One Health vision, a healthcare model based on the integration of various disciplines, is both ancient and current. It is based on the recognition that human health, animal health and ecosystem health are inextricably linked. Cognizant of the need for multidisciplinary research to address complex health challenges at the national and international level, the book combines legal, public policy and medical perspectives on the One Health approach, exploring e.g. the role of biodiversity, human rights, trade agreements, indigenous knowledge, and climate change mitigation and adaptation. One Health is officially recognized by the European Commission and by a host of international organizations as a relevant strategy for actors in all sectors that benefit from collaboration between disciplines (doctors, veterinarians, lawyers, environmentalists, economists, sociologists etc.). One Health is an ideal approach to achieving global health, as it addresses the needs of the most vulnerable populations based on the intimate relationship between their own health, that of their animals, and that of the environment in which they live, considering the wide spectrum of determinants that emerge from this relationship. Given its scope, the book will be of interest to academics, professionals, and students of all disciplines who engage with the One Health approach.