This book investigates the multifaceted relationships between knowledge structures, technology, geography, and regional science. This includes a scholarly exploration of the role of geographical proximity in knowledge structures (spatial spillovers), the transformative potential of the metaverse in knowledge management, and the historical and cultural influences on modern knowledge ecosystems. It further scrutinizes the impact of technology on knowledge distribution, the guiding role of institutions and organizations in knowledge societies, and the value of cultural diversity for cross-cultural knowledge exchange. Addressing complex ethical, privacy, and accessibility challenges, the book concludes by offering strategic insights for creating sustainable knowledge ecosystems, making it an invaluable resource for researchers and professionals in the intersecting domains of technology, geography, regional science, and beyond.