This book investigates the sustainability performance of system that use microgrids in desalination processes. Climate change may be especially dramatic in its effects on island environments. In these environments, aquifers and wells could become over exploited resulting the use of desalination plans. The synergies between water, energy, and food sectors have been identified as vital in achieving the United Nation Sustainable Development Goals. The book explores desalination and microgrids technically as well the economic and legal aspects that must be considered in order explore their techno-economic feasibility - analyzing how to improve the desalination process, proposing a method to locate and size a microgrid. Other synergies between the water, energy, and food system are discussed and the benefits to society that might result in these systems. Also, the lessons learned are highlighted in the context of how they may apply to other sustainable enterprises.