This book presents cutting-edge work on innovative planning methodologies, tools and experiences aimed at supporting the transition of our cities and regions towards a more smart and sustainable dimension. This book comprises a selection of the best papers presented at the international conference “Smart and Sustainable Planning for Cities and Regions 2015�, held in November 2015 in Bolzano, Italy. Contributions from different research fields within urban and regional planning from the scientific as well as the professional community are presented: energy planning for cities and regions, how to couple the energy-climate goals with the development or renovation of the built environment and how to tackle the vulnerability to climate change; smart and sustainable technologies, big data, integrated infrastructures and mobility management, from holistic geospatial tools to innovative apps and Internet of Things; benefits, costs and opportunities of urban transition toward a more smart and sustainable dimension, accounting and assessment of values and trade-offs within the decision making processes; governance for smart and sustainable growth, fostering place-based policy-making, active and effective stakeholders’ participation, co-production and public-private partnerships; cooperation and demonstration projects: their role in fostering the adoption of new approaches and technologies, towards the development of win-win solutions.