This thesis makes significant advances in the quantitative understanding of two intrinsically linked yet technically very different phenomena in quantum chromodynamics (QCD).  Firstly, the thesis investigates the soft probe of strong interaction topological fluctuations in the quark-gluon plasma (QGP) which is made possible via the anomalous chiral transport effects induced by such fluctuations. Here, the author makes contributions towards establishing the first comprehensive tool for quantitative prediction of the chiral magnetic effect in the QGP that is produced in heavy ion collision experiments. Secondly, the thesis deals with the hard probe of strongly coupled QGP created in heavy-ion collisions. In particular, this study addresses the basic question related to the nonperturbative color structure in the QGP via jet energy loss observables. The author further develops the CUJET computational model for jet quenching and uses it to analyze the topological degrees of freedom in quark-gluon plasma. The contributions this thesis makes towards these highly-challenging problems have already generated widespread impacts in the field of quark-gluon plasma and high-energy nuclear collisions.