The hERG Cardiac Potassium Channel - E-book

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The Herg Cardiac Potassium Channel - ENG

Structure, Function And Long Qt Syndrome

Derek J. Chadwick; Jamie A. Goode

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Sinopsis

ISBN:	9780470021415
Formato:	Page Fidelity
Idioma:	Inglés
Editorial:	Wiley Global Research (STMS)
Tema:	Ciencia
Subtema:	Ciencias de la Vida biología celular
Año de publicación:	2005-06-14

This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.Â It features regulatory authority perspectives on preferred preclinical test systems and includes topics onÂ hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.Â Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

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