This Handbook explores the interactions within the Euro-Latin American region and analyzes the interests, norms, and practices of actors influencing the governance of interregional issues and policies. The chapters examine how states and non-state players in the Atlantic region tackle issues related to asymmetries, development disparities, and adaptation to the global system. Eight sections cover the unique characteristics of the interregional connections between the European Union (EU) and Latin America. The first examines multiple perspectives on defining and understanding Euro-Latin American Space, and the second continues with explaining the role of three leading EU institutions in the relationship with Latin America. EU relations with Latin American regions and some individual countries are the subject of sections three and four. The economic and political bi-regional agendas are explored in sections five and six. This Handbook closes with two sections focused on the societal experiences and the role of external actors.