This book provides a comprehensive exploration of Tomato Leaf Curl New Delhi Virus (ToLCNDV), a Begomovirus of the Geminiviridae family, which has become a major threat to global horticultural and field crops. The chapters delve into various aspects, beginning with the viruss genome structure, biology, and molecular mechanisms of infection. It also covers host-pathogen interactions, virome dynamics, and the epidemiology of ToLCNDV, including vector dynamics and non-vector transmission routes. Advanced topics such as dsRNA, genome editing, nanotechnology, and biocontrol strategies for managing ToLCNDV are also included. This book is a valuable resource for researchers, plant pathologists, virologists, crop growers, and students interested in plant virus management and epidemiology.