Treatment-resistant schizophrenia is one of the most challenging mental health disorders and is associated with a high risk of relapse, repeated hospitalizations, suicidal behavior and poor quality of life. This book focuses on treatment-resistant schizophrenia, its clinical features, and evidence-based treatments: pharmacotherapy, cognitive-behavioral psychotherapy, and rehabilitation. A novel therapy targeting long-term recovery for treatment-resistant schizophrenia is discussed. The cognitive, metacognitive, and recovery perspectives represent the main elements. Each chapter begins with an abstract, followed by learning objectives, introduction, main text, discussion, conclusion, review questions, and bibliography. This structure, including learning objectives and review questions, reinforces the readers learning process. It can also help improve the teaching process in seminars and courses.