This book which is the second edition of Your Passport to a Career in Bioinformatics, is intended for students who plan to work in bioinformatics. In addition to addressing the opportunities and challenges faced by today bioinformatics community, it demonstrates how bioinformatics is currently transitioning from research to vocation and avocation. Further, it extols the virtues of in silico for bioinformatics predictions, as it helps wet-lab biologists reduce the time needed for experiments. In turn, the book addresses career prospects and the Ten Commandments for becoming a bioinformatics professional; bioinformatics for developing countries; bioinformatics for schools; bioinformatics for markets; and the knowns and unknowns of bioinformatics. It also explores how bioinformatics interacts with various fields in terms of three Cs: consistency, continuity, and credibility.