This book reports on the results of a four-year collaborative project between the German Aerospace Center (DLR), three German universities and the aircraft industry. The project was funded by the Ministry for Economic Affairs and Climate Action. In the book, different subprojects are presented, with their corresponding case studies. Readers will find extensive information on simulation strategies required for virtual flight testing, and verification and validation aspects. All in all, this book offers a timely update on the state-of-the-art in flow simulation techniques, flight mechanics methods, integrated multidisciplinary simulation, reduced-order models, and  on the development of processes for automated generation of aerodynamic databases. It addresses both researchers and professionals in the field of aviation engineering.