This standard work on statistical methods in life sciences and medicine provides easily understandable, illustrative, and practical guidance to students, lecturers and practitioners alike, covering all necessary methods for targeted and careful data collection, analysis, and evaluation. In addition to offering advice and recommendations on study planning and analysis, numerous examples, cross-references, further references and a detailed index provide a comprehensive approach to statistics. The consistent use of the freely available programming language R further facilitates the entry for curious users and practitioners. The book serves as a learning, reference, and application tool for individuals with varying levels of expertise and diverse interests, catering to anyone interested in the analysis of correctly acquired data – especially biologists, medical professionals, engineers and other natural scientists – both in academia and in practice. This book is a translation of the original German edition ‘Angewandte Statistik’ by Jürgen Hedderich and Lothar Sachs, 17th edition, published by Springer-Verlag GmbH, DE in 2020. The translation was done with the help of artificial intelligence. A subsequent human revision by Jürgen Hedderich was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.