This book presents the latest technology of sustainable nanomaterials for applications as drug delivery cargos in tackling various inflammatory diseases. The chapters in this book describe nanotechnology-based drug delivery strategies, the mechanistic insights of nanoformulations and their application in managing inflammation diseases such as rheumatoid arthritis, ulcerative colitis, cancer and neurological disorder. It looks into the challenges of using nanomaterials-based smart materials for enhanced therapeutic efficacy while maintaining safe and sustainable procedures. The book is divided into three main sections: A) Fundamental of smart nanocarriers and nanoformulations targeted drug delivery in inflammatory disease; B) Smart nano drug delivery therapy- an emerging approach towards inflammatory diseases and C) Novel nano delivery strategies in targeting major inflammatory diseases. The book targets early researchers and clinical practitioners who are interested in the management and treatment of inflammatory diseases using nanotechnology-based drug delivery systems.